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This is consistent with data showing that protein expression in the gastric mucosa is developmentally regulated Hong et al. FAP was localized in the deep invasive front of the gastric cancers Lee et al. The apoptotic cells induce the apoptosis of macrophages M1 polarization , and also provide danger signals heat shock proteins, etc. The apoptotic cell-induced apoptosis of macrophages is critical in the maintenance of the homeostasis of tissue. It has also been proposed that the FAP expression in the mucosal tissue may be a crucial factor that protects against stomach cancer Wang and Frank, [ B72].

This study provided data to support the hypothesis that FAP is not associated with a particular histological type of gastric cancer. The specific site of over-expression of FAP in the malignant tissues also indicates the involvement of FAP in the pathogenesis of cancers. Using cell-based mouse models, it has been demonstrated that FAP promotes gastric carcinogenesis Ferrara et al.

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Adobe Page Maker Crack Free Download is compelling software for developing various types of documents containing images, graphics, text, themes. Furthermore, it includes several features for integration with other software.


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